Clonal screens to find modifiers of partially penetrant phenotypes in C. elegans.

doi:10.1007/978-1-4939-0992-6_13

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Article

Clonal screens to find modifiers of partially penetrant phenotypes in C. elegans.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Hurwitz Michael E

Abstract excerpt

Unbiased genetic screens are an excellent way to discover novel genes involved in specific biological processes in vivo. Modifier screens, whether to suppress or enhance a phenotype, are a powerful way to find proteins that modulate biological processes responsible for specific phenotypes. However, modification of phenotypes that are only partially penetrant, which is often the case, are often extremely difficult...

Topics

Animals
Caenorhabditis elegans
Genetic Association Studies
Genetic Testing
Mutagenesis
Penetrance
Phenotype

Source

Open in PubMed

Identifiers

PMID: 25030926
DOI: 10.1007/978-1-4939-0992-6_13

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