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DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

16 Jul 2014

Abstract excerpt

We previously identified the heterogeneous ribonucleoprotein SAF-A/hnRNP U as a substrate for DNA-PK, a protein kinase involved in DNA damage response (DDR). Using laser micro-irradiation in human cells, we report here that SAF-A exhibits a two-phase dynamics at sites of DNA damage, with a rapid and transient recruitment followed by a prolonged exclusion. SAF-A recruitment corresponds to its binding to...

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PMID: 25030905
DOI: 10.1093/nar/gku601

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