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Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

16 Jul 2014

Abstract excerpt

Brucella spp. are Gram-negative bacteria that behave as facultative intracellular parasites of a variety of mammals. This genus includes smooth (S) and rough (R) species that carry S and R lipopolysaccharides (LPS), respectively. S-LPS is a virulence factor, and mutants affected in the S-LPS O-polysaccharide (R mutants), core oligosaccharide or both show attenuation. However, B. ovis is naturally R and is...

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PMID: 25029920
DOI: 10.1186/s13567-014-0072-0

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