Article
Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export.
PloS one - 23 Jul 2008
González David, Grilló María-Jesús, De Miguel María-Jesús, Ali Tara, Arce-Gorvel Vilma, Delrue Rose-May, Conde-Alvarez Raquel, Muñoz Pilar, López-Goñi Ignacio, Iriarte Maite, Marín Clara-M, Weintraub Andrej, Widmalm Göran, Zygmunt Michel, Letesson Jean-Jacques, Gorvel Jean-Pierre, Blasco José-María, Moriyón Ignacio
Abstract excerpt
BACKGROUND: The brucellae are facultative intracellular bacteria that cause brucellosis, one of the major neglected zoonoses. In endemic areas, vaccination is the only effective way to control this disease. Brucella melitensis Rev 1 is a vaccine effective against the brucellosis of sheep and goat caused by B. melitensis, the commonest source of human infection. However, Rev 1 carries a smooth lipopolysaccharide...
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