Molecular insights into the assembly and diversity of the outer core oligosaccharide in lipopolysaccharides from Escherichia coli and Salmonella.

doi:10.1179/096805103225001440

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Article

Molecular insights into the assembly and diversity of the outer core oligosaccharide in lipopolysaccharides from Escherichia coli and Salmonella.

Journal of endotoxin research - 1 Jan 2003

Whitfield Chris, Kaniuk Natalia, Frirdich Emilisa

Abstract excerpt

In the Enterobacteriaceae, the core oligosaccharide provides the junction between the highly conserved lipid A and the remarkably diverse polysaccharide O antigen. The basic structure of the inner (lipid A-proximal) core is well conserved, perhaps reflecting constraints imposed by its involvement in the structural integrity of the outer membrane. However, non-stoichiometric modifications do create some structural...

Topics

Escherichia coli
Genetic Variation
Glycosyltransferases
Lipopolysaccharides
Oligosaccharides
Salmonella
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 12935355
DOI: 10.1179/096805103225001440

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