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Brucella melitensis Rev1Δwzm: Placental pathogenesis studies and safety in pregnant ewes

15 May 2024

Abstract excerpt

One of the main causes of human brucellosis is Brucella melitensis infecting small ruminants. To date, Rev1 is the only vaccine successfully used to control ovine and caprine brucellosis. However, it is pathogenic for pregnant animals, resulting in abortions and vaginal and milk shedding, as well as being infectious for humans. Therefore, there is an urgent need to develop an effective vaccine that is safer than...

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PMID: 38755066
DOI: 10.1016/j.vaccine.2024.04.085

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