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Article

Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival.

Infection and immunity - 1 Mar 1998

Allen C A, Adams L G, Ficht T A

Abstract excerpt

The O antigen of Brucella abortus has been described as a major virulence determinant based on the attenuated survival of fortuitously isolated rough variants. However, the lack of genetic definition of these mutants and the virulence of naturally occurring rough species, Brucella ovis and Brucella canis, has confused interpretation. To better characterize the role of O antigen in virulence and survival,...

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Identifiers

PMID: 9488389
DOI: 10.1128/IAI.66.3.1008-1016.1998
PMCID: PMC108009

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