Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival.

doi:10.1128/IAI.66.3.1008-1016.1998

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Article

Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival.

Infection and immunity - 1 Mar 1998

Allen C A, Adams L G, Ficht T A

Abstract excerpt

The O antigen of Brucella abortus has been described as a major virulence determinant based on the attenuated survival of fortuitously isolated rough variants. However, the lack of genetic definition of these mutants and the virulence of naturally occurring rough species, Brucella ovis and Brucel...

Topics

Amino Acid Sequence
Animals
Brucella abortus
Complement System Proteins
DNA Transposable Elements
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
O Antigens
Phagocytosis
Polymyxin B
Virulence

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