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Deletion ofwboAEnhances Activation of the Lectin Pathway of Complement inBrucella abortusandBrucella melitensis

1 Jul 2001

Abstract excerpt

Brucella spp. are gram-negative intracellular pathogens that survive and multiply within phagocytic cells of their hosts. Smooth organisms present O polysaccharides (OPS) on their surface. These OPS help the bacteria avoid the bactericidal action of serum. The wboA gene, coding for the enzyme glycosyltransferase, is essential for the synthesis of O chain in Brucella. In this study, the sensitivity to serum of...

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PMID: 11401980
DOI: 10.1128/iai.69.7.4407-4416.2001

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