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Article

H-Ras regulation of TRAIL death receptor mediated apoptosis.

Oncotarget - 15 Jul 2014

Chen Jun-Jie, Bozza William P, Di Xu, Zhang Yaqin, Hallett William, Zhang Baolin

Abstract excerpt

TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis through the death receptors (DRs) 4 and/or 5 expressed on the cell surface. Multiple clinical trials are underway to evaluate the antitumor activity of recombinant human TRAIL and agonistic antibodies to DR4 or DR5. However, their therapeutic potential is limited by the high frequency of cancer resistance. Here we provide evidence demonstrating the...

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Source

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Identifiers

PMID: 25026275
DOI: 10.18632/oncotarget.2091
PMCID: PMC4148127

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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