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Article

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.

The EMBO journal - 1 Apr 1999

Peli J, Schröter M, Rudaz C, Hahne M, Meyer C, Reichmann E, Tschopp J

Abstract excerpt

Tumor growth is the result of deregulated tissue homeostasis which is maintained through the delicate balance of cell growth and apoptosis. One of the most efficient inducers of apoptosis is the death receptor Fas. We report here that oncogenic Ras (H-Ras) downregulates Fas expression and renders cells of fibroblastic and epitheloid origin resistant to Fas ligand-induced apoptosis. In Ras-transformed cells, Fas...

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Identifiers

PMID: 10202146
DOI: 10.1093/emboj/18.7.1824
PMCID: PMC1171268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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