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Article

The TRAIL apoptotic pathway in cancer onset, progression and therapy.

Nature reviews. Cancer - 1 Oct 2008

Johnstone Ricky W, Frew Ailsa J, Smyth Mark J

Abstract excerpt

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized, as have the signals that are generated when these receptors are activated. TNF-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy. Herein we review what is known about the...

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Identifiers

PMID: 18813321
DOI: 10.1038/nrc2465

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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