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Article

Involvement of DR4/JNK pathway-mediated autophagy in acquired TRAIL resistance in HepG2 cells

20 Sept 2016

Abstract excerpt

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent, a number of cancer cells demonstrate TRAIL resistance. To date, various molecular targets leading to TRAIL resistance have been elucidated by many researchers, but the mechanisms involved are still not fully understood. In the present study, we obtained TRAIL-resistant cells from the human hepatocellular...

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PMID: 27665736
DOI: 10.3892/ijo.2016.3699

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