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Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss.

Hippocampus - 1 Jul 2015

Ager Rahasson R, Davis Joy L, Agazaryan Andy, Benavente Francisca, Poon Wayne W, LaFerla Frank M, Blurton-Jones Mathew

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder, affecting over 35 million people worldwide. Pathologically, AD is characterized by the progressive accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles within the brain. Together, these pathologies lead to marked neuronal and synaptic loss and corresponding impairments in cognition. Current treatments, and recent...

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Identifiers

PMID: 25530343
DOI: 10.1002/hipo.22405
PMCID: PMC4722865

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