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Article

Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer's disease.

Transgenic research - 1 Jun 2013

Yamamoto Satoshi, Ooshima Yuki, Nakata Mitsugu, Yano Takashi, Matsuoka Kunio, Watanabe Sayuri, Maeda Ryouta, Takahashi Hideki, Takeyama Michiyasu, Matsumoto Yoshio, Hashimoto Tadatoshi

Abstract excerpt

Gene-targeting technology using mouse embryonic stem (ES) cells has become the "gold standard" for analyzing gene functions and producing disease models. Recently, genetically modified mice with multiple mutations have increasingly been produced to study the interaction between proteins and polygenic diseases. However, introduction of an additional mutation into mice already harboring several mutations by...

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PMID: 22961199
DOI: 10.1007/s11248-012-9651-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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