Article
Defunctioning polymorphism in the immunoglobulin G inhibitory receptor (FcγRIIB-T/T232) does not impact on kidney transplant or recipient survival.
Transplantation - 15 Aug 2014
Clatworthy Menna R, Matthews Rebeccah J, Doehler Bernd, Willcocks Lisa C, Opelz Gerhard, Smith Kenneth G C
Abstract excerpt
BACKGROUND: There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells. Most FcγRs are activating and controlled by a single inhibitory receptor, FcγRIIB (CD32B),...
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