LILRB3 genetic variation is associated with kidney transplant failure in African American recipients.

doi:10.1038/s41591-025-03568-z

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Article

LILRB3 genetic variation is associated with kidney transplant failure in African American recipients.

Nature medicine - 1 May 2025

Sun Zeguo, Yi Zhengzi, Wei Chengguo, Wang Wenlin, Ren Tianyuan, Cravedi Paolo, Tedla Fasika, Ward Stephen C, Azeloglu Evren, Schrider Daniel R, Li Yun, Khan Atlas, Zanoni Francesca, Fu Jia, Ali Sumaria, Liu Shun, Liang Deguang, Liu Tong, Li Hong, Xi Caixia, Vy Thi Ha, Mosoyan Gohar, Sun Quan, Kumar Ashwani, Zhang Zhongyang, Farouk Samira, Campell Kirk, Ochando Jordi, Lee Kyung, Coca Steve, Xiang Jenny, Connolly Patricia, Gallon Lorenzo, O'Connell Philip J, Colvin Robert, Menon Madhav C, Nadkarni Girish, He John C, Kraft Monica, Jiang Xuejun, Zhang Xuewu, Kiryluk Krzysztof, Cherukuri Aravind, Lakkis Fadi G, Zhang Weiguo, Chen Shu-Hsia, Heeger Peter S, Zhang Weijia

Abstract excerpt

African American (AA) kidney transplant recipients exhibit a higher rate of graft loss compared with other racial and ethnic populations, highlighting the need to identify causative factors. Here, in the Genomics of Chronic Allograft Rejection cohort, pretransplant blood RNA sequencing revealed a cluster of four consecutive missense single-nucelotide polymorphisms (SNPs), within the leukocyte immunoglobulin-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40065170
DOI: 10.1038/s41591-025-03568-z
PMCID: PMC12527113

Genes

LILRB3
APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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