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A novel Kit mutant rat enables hematopoietic stem cell engraftment without irradiation.

Experimental hematology - 1 Apr 2024

Iida Ryuya, Ishida Saeko, Wang Jinxi, Hattori Kosuke, Yoshimi Kazuto, Yamazaki Satoshi, Mashimo Tomoji

Abstract excerpt

Hematopoietic stem cell (HSC) transplantation is extensively studied in mouse models, but their limited scale presents challenges for effective engraftment and comprehensive evaluations. Rats, owing to their larger size and anatomical similarity to humans, offer a promising alternative. In this study, we establish a rat model with the KitV834M mutation, mirroring KitW41 mice often used in KIT signaling and HSC...

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Identifiers

PMID: 38331018
DOI: 10.1016/j.exphem.2024.104174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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