Article
Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements.
Nature communications - 10 Jul 2014
Muratani Masafumi, Deng Niantao, Ooi Wen Fong, Lin Suling Joyce, Xing Manjie, Xu Chang, Qamra Aditi, Tay Su Ting, Malik Simeen, Wu Jeanie, Lee Ming Hui, Zhang Shenli, Tan Luke Lin Chuen, Chua Huihoon, Wong Wai Keong, Ong Hock Soo, Ooi London Lucien, Chow Pierce Kah-How, Chan Weng Hoong, Soo Khee Chee, Goh Liang Kee, Rozen Steve, Teh Bin Tean, Yu Qiang, Ng Huck Hui, Tan Patrick
Abstract excerpt
Chromatin alterations are fundamental hallmarks of cancer. To study chromatin alterations in primary gastric adenocarcinomas, we perform nanoscale chromatin immunoprecipitation sequencing of multiple histone modifications in five gastric cancers and matched normal tissues. We identify hundreds of somatically altered promoters and predicted enhancers. Many cancer-associated promoters localize to genomic sites...
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