Article

Up-And-Down γ-Synuclein Transcription in Dopamine Neurons Translates Into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice

2022-01-12

Abstract excerpt

The synuclein family consists of α-, β-, and γ-Synuclein (α-Syn, β-Syn, and γ-Syn), expressed in the neurons and concentrated in synaptic terminals. While α-Syn is at the center of interest due to its implication in the pathogenesis of Parkinson’s disease (PD) and other synucleinopathies, limited information exists on the other members. The current study aimed at inves...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 991b3c96-9cc1-599d-9e09-611c89c4f93d
DOI: 10.20944/preprints202201.0173.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Up-And-Down γ-Synuclein Transcription in Dopamine Neurons Translates Into Changes in Dopamine Neurotransmission and Behavioral Performance in MiceDOI 10.20944/preprints202201.0173.v1Read

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.Semantic proximity Read

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.Semantic proximity Read

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neuronsSemantic proximity Read

Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.Semantic proximity Read

α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal ModelsSemantic proximity Read

Roles for α-Synuclein in Gene ExpressionSemantic proximity Read

Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic MiceSemantic proximity Read

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and InterventionSemantic proximity Read

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse proteinSemantic proximity Read

Accelerated and Localized Synucleinopathy in a Hybrid Mouse Model: Implications for Positron Emission Tomography StudiesSemantic proximity Read

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.Semantic proximity Read

Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy.Semantic proximity Read