A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.

doi:10.1093/brain/aws358

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Article

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.

Brain : a journal of neurology - 1 Feb 2013

Nuber Silke, Harmuth Florian, Kohl Zacharias, Adame Anthony, Trejo Margaritha, Schönig Kai, Zimmermann Frank, Bauer Claudia, Casadei Nicolas, Giel Christiane, Calaminus Carsten, Pichler Bernd J, Jensen Poul H, Müller Christian P, Amato Davide, Kornhuber Johannes, Teismann Peter, Yamakado Hodaka, Takahashi Ryosuke, Winkler Juergen, Masliah Eliezer, Riess Olaf

Abstract excerpt

Conversion of soluble α-synuclein into insoluble and fibrillar inclusions is a hallmark of Parkinson's disease and other synucleinopathies. Accumulating evidence points towards a relationship between its generation at nerve terminals and structural synaptic pathology. Little is known about the pathogenic impact of α-synuclein conversion and deposition at nigrostriatal dopaminergic synapses in transgenic mice,...

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PMID: 23413261
DOI: 10.1093/brain/aws358
PMCID: PMC3572936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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