Article
The roles of thiol oxidoreductases in yeast replicative aging.
Mechanisms of ageing and development - 1 Jan 2000
Hacioglu Elise, Esmer Isil, Fomenko Dmitri E, Gladyshev Vadim N, Koc Ahmet
Abstract excerpt
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span...
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