The BDNF Val66Met polymorphism modulates the generalization of cued fear responses to a novel context.

doi:10.1038/npp.2013.320

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Article

The BDNF Val66Met polymorphism modulates the generalization of cued fear responses to a novel context.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2014

Mühlberger Andreas, Andreatta Marta, Ewald Heike, Glotzbach-Schoon Evelyn, Tröger Christian, Baumann Christian, Reif Andreas, Deckert Jürgen, Pauli Paul

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) has a crucial role in activity-dependent synaptic plasticity and learning and memory. The human functional single-nucleotide BDNF rs6265 (Val66Met) polymorphism has been found to be associated with alteration in neural BDNF release and function correlating with altered emotional behavior. Here, we investigated for the first time the hypothesis that this polymorphism in...

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Identifiers

PMID: 24247044
DOI: 10.1038/npp.2013.320
PMCID: PMC3957113

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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