Article
Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein.
The American journal of tropical medicine and hygiene - 1 May 2012
Gandhi Kavita, Thera Mahamadou A, Coulibaly Drissa, Traoré Karim, Guindo Ando B, Doumbo Ogobara K, Takala-Harrison Shannon, Plowe Christopher V
Abstract excerpt
The malaria vaccine RTS,S/AS01, based on immunogenic regions of the Plasmodium falciparum circumsporozoite protein (CSP), has partial efficacy against clinical malaria in African children. Understanding how sequence diversity in CSP T- and B-cell epitopes relates to naturally acquired and vaccine-induced immunity may be useful in efforts to improve the efficacy of CSP-based vaccines. However, limitations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.