Article
Ca2+ regulation of PMCA2 calcium pump expression in hair cells of Tmc1 deafness mutants.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2026
Rolseth Amanda Bryn, Beurg Maryline, Konrad Dakota Elle, August Benjamin K, Fettiplace Robert
Abstract excerpt
Mutations in transmembrane channel-like protein 1 (TMC1), the pore-forming component of the mechano-electrical transducer (MET) channel in auditory hair cells, cause cell death and deafness in 3-wk old mice. We studied mice with mutations Tmc1 p.T416K, p.M412K, p.D528N, and p.D569N, which possessed functional MET channels at postnatal day (P)6 but became deaf before P21. These Tmc1 mutants had channels with...
Topics
- Animals
- Plasma Membrane Calcium-Transporting ATPases
- Calcium
- Mice
- Membrane Proteins
- Deafness
- Mutation
- Hair Cells, Auditory
- Stereocilia
- Hair Cells, Auditory, Outer