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Article

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).

eLife - 23 May 2017

Erickson Timothy, Morgan Clive P, Olt Jennifer, Hardy Katherine, Busch-Nentwich Elisabeth, Maeda Reo, Clemens Rachel, Krey Jocelyn F, Nechiporuk Alex, Barr-Gillespie Peter G, Marcotti Walter, Nicolson Teresa

Abstract excerpt

Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt-deficient hair cells. GFP-tagged Tomt is enriched in the Golgi of hair cells, suggesting that...

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Share to Disease Models, Animal
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss, Sensorineural

Share to Mechanotransduction, Cellular

Share to Membrane Proteins

Share to Methyltransferases

Share to Zebrafish

Share to Zebrafish Proteins

Source

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Identifiers

PMID: 28534737
DOI: 10.7554/eLife.28474
PMCID: PMC5462536

Genes

MET
TOMT
LRTOMT
TMC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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