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Article

Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations.

American journal of physiology. Lung cellular and molecular physiology - 15 Aug 2014

Platé Manuela, Lawson Phillippa J, Hill Michael R, Quint Jennifer K, Kumari Meena, Laurent Geoffrey J, Wedzicha Jadwiga A, Chambers Rachel C, Hurst John R

Abstract excerpt

Proteinase-activated receptor-1 (PAR-1) plays a key role in mediating the interplay between coagulation and inflammation in response to injury. The aim of this study was to investigate the role of the promoter single-nucleotide polymorphism (SNP) rs2227744G>A in modulating PAR-1/F2R gene expressi...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Pulmonary Disease, Chronic Obstructive

Share to Receptor, PAR-1

Source

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Identifiers

PMID: 24973402
DOI: 10.1152/ajplung.00128.2014
PMCID: PMC4137163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24973402-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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