Article
[The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages].
Molekuliarnaia biologiia - 1 Jan 2024
Uvarova A N, Tkachenko E A, Stasevich E M, Bogomolova E A, Zheremyan E A, Kuprash D V, Korneev K V
Abstract excerpt
The complement inhibitor CD55/DAF is expressed on many cell types. Dysregulation of CD55 expression is associated with increased disease severity in influenza A infection and vascular complications in pathologies that involve excessive activation of the complement system. A luciferase reporter system was used to functionally analyze the single nucleotide polymorphism rs2564978 in the U937 human promonocytic cell...
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