Article
Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease.
The European respiratory journal - 1 Nov 2001
Hirano K, Sakamoto T, Uchida Y, Morishima Y, Masuyama K, Ishii Y, Nomura A, Ohtsuka M, Sekizawa K
Abstract excerpt
Proteinase/antiproteinase imbalance is the most widely accepted theory for development of chronic obstructive pulmonary disease (COPD). Mutations of tissue inhibitor of metalloproteinases-2 (TIMP-2) that downregulate its activity may increase the activities of matrix metalloproteinases and result in the degradation of the lung matrix. Polymorphisms of the TIMP-2 gene were investigated in 88 COPD patients and 40...
Topics
- Aged
- DNA Primers
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Protease Inhibitors
- Pulmonary Disease, Chronic Obstructive
- RNA, Messenger
- Tissue Inhibitor of Metalloproteinase-2
- Transcription, Genetic