Article
Promoter activity of human tissue inhibitor of metalloproteinase 2 gene with novel single nucleotide polymorphisms.
Respirology (Carlton, Vic.) - 1 Jan 2005
Hegab Ahmed E, Sakamoto Tohru, Uchida Yoshiyuki, Nomura Akihiro, Ishii Yukio, Morishima Yuko, Mochizuki Mie, Kimura Toru, Saitoh Wataru, Iizuka Takashi, Kiwamoto Takumi, Sekizawa Kiyohisa
Abstract excerpt
OBJECTIVE: The single nucleotide polymorphism (SNP) -418G > C in the TIMP2 gene promoter region has been shown to be associated with in chronic obstructive pulmonary disease (COPD). The purpose of this study was to search for novel single nucleotide polymorphism (SNP) in the TIMP2 promoter region around the -418G > C locus, and to investigate whether any of these SNP, including -418G > C, had an influence on...
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