Article
Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
BMC medical genetics - 15 Jan 2010
Haq Imran, Chappell Sally, Johnson Simon R, Lotya Juzer, Daly Leslie, Morgan Kevin, Guetta-Baranes Tamar, Roca Josep, Rabinovich Roberto, Millar Ann B, Donnelly Seamas C, Keatings Vera, MacNee William, Stolk Jan, Hiemstra Pieter S, Miniati Massimo, Monti Simonetta, O'Connor Clare M, Kalsheker Noor
Abstract excerpt
BACKGROUND: Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis of the pathogenesis of COPD. These include the matrix metalloproteinase (MMP) genes which play a role in tissue remodelling and fit in with the protease--antiprotease imbalance theory for the cause of COPD. Previous genetic studies of MMPs...
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