Article
Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2008
Reiner Alexander P, Wurfel Mark M, Lange Leslie A, Carlson Christopher S, Nord Alex S, Carty Cara L, Rieder Mark J, Desmarais Cindy, Jenny Nancy S, Iribarren Carlos, Walston Jeremy D, Williams O Dale, Nickerson Deborah A, Jarvik Gail P
Abstract excerpt
BACKGROUND: Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response. METHODS AND RESULTS: We screened a set of 16 inflammation-related genes for association with CRP in a large population-based study of healthy young adults (n=1627). Results were validated in 2 independent studies (n=1208 and n=4310),...
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