Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypervirulent Group A Streptococcus of Genotype emm3 Invades the Vascular System in Pulmonary Infection of Mice.

Infection and immunity - 1 Jun 2018

Lei Benfang, Minor Dylan, Feng Wenchao, Liu Mengyao

Abstract excerpt

Natural mutations of the two-component regulatory system CovRS are frequently associated with invasive group A Streptococcus (GAS) isolates and lead to the enhancement of virulence gene expression, innate immune evasion, systemic dissemination, and virulence. How CovRS mutations enhance systemic dissemination is not well understood. A hypervirulent GAS isolate of the emm3 genotype, MGAS315, was characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteremia
Share to Bronchoalveolar Lavage Fluid
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Lung Diseases

Share to Streptococcal Infections

Share to Streptococcus pyogenes

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 29610254
DOI: 10.1128/IAI.00080-18
PMCID: PMC5964506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypervirulent Group A Streptococcus of Genotype emm3 Invades the Vascular System in Pulmonary Infection of Mice.PMID 29610254Read ↗

Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface.Semantic proximity Read ↗

Contemporary Pharyngeal and Invasive emm1 and Invasive emm12 Group A Streptococcus Isolates Exhibit Similar In Vivo Selection for CovRS Mutants in Mice.Semantic proximity Read ↗

Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence.Semantic proximity Read ↗

Serotype M3 and M28 Group A Streptococci Have Distinct Capacities to Evade Neutrophil and TNF-α Responses and to Invade Soft Tissues.Semantic proximity Read ↗

Expression microarray and mouse virulence analysis of four conserved two-component gene regulatory systems in group a streptococcus.Semantic proximity Read ↗

Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria.Semantic proximity Read ↗

Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcusSemantic proximity Read ↗

Comparative genomics of Streptococcus pyogenes M1 isolates differing in virulence and propensity to cause systemic infection in mice.Semantic proximity Read ↗

Srv mediated dispersal of streptococcal biofilms through SpeB is observed in CovRS+ strains.Semantic proximity Read ↗

Cellular interactions of covR/S mutant group A Streptococci.Semantic proximity Read ↗

Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease SpecificitySemantic proximity Read ↗

Neutrophils select hypervirulent CovRS mutants of M1T1 group A Streptococcus during subcutaneous infection of mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.