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Article

Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.

BMC research notes - 28 Mar 2013

Tatsuno Ichiro, Okada Ryo, Zhang Yan, Isaka Masanori, Hasegawa Tadao

Abstract excerpt

BACKGROUND: CovRS (or CsrRS) is a two-component regulatory system that regulates the production of multiple virulence factors in Streptococcus pyogenes. covS mutations are often found in isolates recovered from mice that have been experimentally infected with S. pyogenes and covS mutations enhance bacterial virulence in an invasive infection mouse model. In addition, covS mutations were detected more frequently...

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Identifiers

PMID: 23537349
DOI: 10.1186/1756-0500-6-126
PMCID: PMC3637574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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