Article
A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes.
The Journal of biological chemistry - 1 Mar 2013
Liang Zhong, Zhang Yueling, Agrahari Garima, Chandrahas Vishwanatha, Glinton Kristofor, Donahue Deborah L, Balsara Rashna D, Ploplis Victoria A, Castellino Francis J
Abstract excerpt
A skin-tropic invasive group A Streptococcus pyogenes (GAS) strain, AP53, contains a natural inactivating mutation in the covS gene (covS(M)) of the two-component responder (CovR)/sensor (CovS) gene regulatory system. The effects of this mutation on specific GAS virulence determinants have been assessed, with emphasis on expression of the extracellular protease, streptococcal pyrogenic exotoxin B (SpeB), capsular...
Topics
- Animals
- Bacterial Proteins
- Exotoxins
- Genes, Bacterial
- Histidine Kinase
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Mice
- Mutation