Article
Aβ1-42 reduces P-glycoprotein in the blood-brain barrier through RAGE-NF-κB signaling.
Cell death & disease - 26 Jun 2014
Park R, Kook S-Y, Park J-C, Mook-Jung I
Abstract excerpt
The reduced clearance of amyloid-β peptide (Aβ) from the brain partly accounts for the neurotoxic accumulation of Aβ in Alzheimer's disease (AD). Recently, it has been suggested that P-glycoprotein (P-gp), which is an efflux transporter expressed on the luminal membrane of the brain capillary endothelium, is capable of transporting Aβ out of the brain. Although evidence has shown that restoring P-gp reduces brain...
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