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Article

Age-related changes in P-glycoprotein expression in senescence-accelerated mouse.

Current aging science - 1 Dec 2009

Wu Bin, Ueno Masaki, Onodera Masayuki, Kusaka Takashi, Huang Cheng-long, Hosomi Naohisa, Kanenishi Kenji, Sakamoto Haruhiko

Abstract excerpt

P-glycoprotein, the gene product of ATP-binding cassette, sub-family B (Abcb1), is a representative efflux transporter of cerebral vessels. It was recently reported that the expressions of P-glycoprotein and Abcb1 gene were increased in hippocampal vessels with blood-brain barrier (BBB) damage in stroke-prone hypertensive rats. SAMP8, senescence-accelerated mice with age-related deficits in memory and learning,...

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PMID: 20021412
DOI: 10.2174/1874609810902030187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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