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Article

Aβ₁₋₄₂-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca²⁺-calcineurin signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2012

Kook Sun-Young, Hong Hyun Seok, Moon Minho, Ha Chang Man, Chang Sunghoe, Mook-Jung Inhee

Abstract excerpt

The blood-brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of endothelial cells, maintains homeostasis of the brain. Disrupted intracellular Ca²⁺ homeostasis and breakdown of the BBB have been implicated in the pathogenesis of Alzheimer's disease (AD). The receptor for a...

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Identifiers

PMID: 22745485
DOI: 10.1523/JNEUROSCI.6102-11.2012
PMCID: PMC6622350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22745485-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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