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GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer’s disease

3 Jun 2025

Abstract excerpt

BACKGROUND: G protein-coupled receptor 43 (GPR43) is a critical signaling molecule involved in maintaining energy balance and immune homeostasis, making it a widely studied drug target. However, its role in Alzheimer’s disease (AD) remains unclear. This study aims to investigate the effects of GPR43 activation in an Aβ1−42-induced AD mouse model and to elucidate the underlying mechanisms. METHODS: Experiments...

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PMID: 40468230
DOI: 10.1186/s10020-025-01269-4

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