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Article

Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Yang Jing, Lunde Lisa K, Nuntagij Paworn, Oguchi Tomohiro, Camassa Laura M A, Nilsson Lars N G, Lannfelt Lars, Xu Yuming, Amiry-Moghaddam Mahmood, Ottersen Ole Petter, Torp Reidun

Abstract excerpt

Aquaporin-4 (AQP4) is the predominant water channel in brain and is selectively expressed in astrocytes. Astrocytic endfoot membranes exhibit tenfold higher densities of AQP4 than non-endfoot membranes, making AQP4 an excellent marker of astrocyte polarization. Loss of astrocyte polarization is known to compromise astrocytic function and to be associated with impaired water and K+ homeostasis. Here we investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21891870
DOI: 10.3233/JAD-2011-110725

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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