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Article

Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease.

Current Alzheimer research - 1 Jan 2014

Fawver Janelle N, Ghiwot Yonatan, Koola Catherine, Carrera Wesley, Rodriguez-Rivera Jennifer, Hernandez Caterina, Dineley Kelly T, Kong Yu, Li Jianrong, Jhamandas Jack, Perry George, Murray Ian V J

Abstract excerpt

Amyloid formation is the pathological hallmark of type 2 diabetes (T2D) and Alzheimer's disease (AD). These diseases are marked by extracellular amyloid deposits of islet amyloid polypeptide (IAPP) in the pancreas and amyloid β (Aβ) in the brain. Since IAPP may enter the brain and disparate amyloids can cross-seed each other to augment amyloid formation, we hypothesized that pancreatic derived IAPP may enter the...

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Glial Fibrillary Acidic Protein

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Source

Identifiers

PMID: 25387341
DOI: 10.2174/1567205011666141107124538

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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