Article

Identification of a unique transcriptomic signature associated with islet amyloidosis

2022-11-10

Abstract excerpt

<h4>Aims</h4> This cross-sectional study aims to identify potential transcriptomic changes conveyed by presence of amyloid deposits in islets from pancreatic tissue obtained from metabolically profiled living donors. <h4>Methods</h4> After establishing Thioflavin S as the most sensitive approach to detect islet amyloid plaques, we utilized RNA sequencing data obtained from laser capture microdissected islets to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e269171c-61c0-5c62-9dc9-5be89df493c7
DOI: 10.1101/2022.11.09.515784

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a unique transcriptomic signature associated with islet amyloidosisDOI 10.1101/2022.11.09.515784Read

Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic CasesSemantic proximity Read

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetesSemantic proximity Read

Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donorsSemantic proximity Read

Transcriptomic Architecture of Type 2 Diabetes in Human Pancreatic Islets: An Integrative Meta-Analysis and Machine Learning Framework for Biomarker DiscoverySemantic proximity Read

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetesSemantic proximity Read

IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetesSemantic proximity Read

Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetesSemantic proximity Read

Integrated Systems Analysis Deciphers Transcriptome and Glycoproteome Links in Alzheimer’s DiseaseSemantic proximity Read

Single-cell and pseudobulk transcriptomic profiling reveals immune-enriched disease- associated signatures in human pancreatic islets from type 2 diabetesSemantic proximity Read

Amyloid Typing by Mass Spectrometry in Clinical Practice: a Comprehensive Review of 16,175 SamplesSemantic proximity Read

An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 DiabetesSemantic proximity Read

Islet Gene View - a tool to facilitate islet researchSemantic proximity Read