Article
SNP association mapping across the extended major histocompatibility complex and risk of B-cell precursor acute lymphoblastic leukemia in children.
PloS one - 1 Jan 2013
Urayama Kevin Y, Chokkalingam Anand P, Metayer Catherine, Hansen Helen, May Suzanne, Ramsay Patricia, Wiemels Joseph L, Wiencke John K, Trachtenberg Elizabeth, Thompson Pamela, Ishida Yasushi, Brennan Paul, Jolly Kent W, Termuhlen Amanda M, Taylor Malcolm, Barcellos Lisa F, Buffler Patricia A
Abstract excerpt
The extended major histocompatibility complex (xMHC) is the most gene-dense region of the genome and harbors a disproportionately large number of genes involved in immune function. The postulated role of infection in the causation of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) suggests that the xMHC may make an important contribution to the risk of this disease. We conducted association...
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