Article
Rare allelic forms of PRDM9 associated with childhood leukemogenesis.
Genome research - 1 Mar 2013
Hussin Julie, Sinnett Daniel, Casals Ferran, Idaghdour Youssef, Bruat Vanessa, Saillour Virginie, Healy Jasmine, Grenier Jean-Christophe, de Malliard Thibault, Busche Stephan, Spinella Jean-François, Larivière Mathieu, Gibson Greg, Andersson Anna, Holmfeldt Linda, Ma Jing, Wei Lei, Zhang Jinghui, Andelfinger Gregor, Downing James R, Mullighan Charles G, Awadalla Philip
Abstract excerpt
One of the most rapidly evolving genes in humans, PRDM9, is a key determinant of the distribution of meiotic recombination events. Mutations in this meiotic-specific gene have previously been associated with male infertility in humans and recent studies suggest that PRDM9 may be involved in pathological genomic rearrangements. In studying genomes from families with children affected by B-cell precursor acute...
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