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Article

ATF3 confers resistance to pneumococcal infection through positive regulation of cytokine production.

The Journal of infectious diseases - 1 Dec 2014

Nguyen Cuong Thach, Kim Eun-Hye, Luong Truc Thanh, Pyo Suhkneung, Rhee Dong-Kwon

Abstract excerpt

BACKGROUND: Activating transcription factor-3 (ATF3) is known as a suppressor of cytokine production after exposure to lipopolysaccharide or during gram-negative bacterial infection. However, the mechanism by which ATF3 regulates innate immunity against gram-positive bacterial infection, particularly Streptococcus pneumoniae, remains unknown. METHODS: The wild-type and ATF3 knock-out (KO) mice were infected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24951825
DOI: 10.1093/infdis/jiu352

Genes

ATF3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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