Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing Roles for Interferon Regulatory Factor-3 (IRF-3) and Type I Interferon Signaling during Plague

26 Jul 2012

Abstract excerpt

Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells. For bacterial infection, IFN-I signaling can result in widely variant responses, in some cases contributing to the pathogenesis of disease while in others contributing to host defense....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herbal Medicine Research Studies
Share to Pharmacological Effects of Natural Compounds
Share to Yersinia bacterium, plague, ectoparasites research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22911267
DOI: 10.1371/journal.ppat.1002817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing Roles for Interferon Regulatory Factor-3 (IRF-3) and Type I Interferon Signaling during PlaguePMID 22911267Read ↗

Confounding roles for type I interferons during bacterial and viral pathogenesis.Semantic proximity Read ↗

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3Semantic proximity Read ↗

Hijacking of the pleiotropic cytokine interferon-γ by the type III secretion system of Yersinia pestis.Semantic proximity Read ↗

Role of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus in murine macrophages and fibroblastsSemantic proximity Read ↗

Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus ReplicationSemantic proximity Read ↗

Regulation of type I and type III interferon induction in response to pathogen sensingSemantic proximity Read ↗

The Transcription Factor IRF3 Triggers “Defensive Suicide” Necrosis in Response to Viral and Bacterial PathogensSemantic proximity Read ↗

Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.Semantic proximity Read ↗

The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic AlphavirusesSemantic proximity Read ↗

Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN-γ-Mediated Inhibition of Norovirus Replication in MacrophagesSemantic proximity Read ↗

Inhibition of type III secretion system induced leukotriene B <sub>4</sub> production by <i>Yersinia pestis</i> : A mechanism for early immune evasionSemantic proximity Read ↗

Interaction between Yersinia pestis and the Host Immune SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.