Article
Expression and gene variation studies deny association of human HSD3B1 gene with aldosterone production or blood pressure.
American journal of hypertension - 1 Jan 2015
Verwoert Germaine C, Hofland Johannes, Amin Najaf, Mattace-Raso Francesco U S, Sijbrands Eric J G, Hofman Albert, van den Meiracker Anton H, Uitterlinden André G, van Duijn Cornelia M, de Jong Frank H, Danser A H Jan
Abstract excerpt
BACKGROUND: Recent evidence suggests that the type I 3β-hydroxysteroid dehydrogenase, a steroidogenic enzyme encoded by the HSD3B1 gene, could be involved in aldosterone production and that genetic variation in HSD3B1 is associated with blood pressure. These findings challenge the long-standing hypothesis that all adrenocortical steroidogenesis is executed by the type II iso-enzyme, encoded by HSD3B2. METHODS: To...
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