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Congenital Adrenal Hyperplasia due to 3β-Hydroxysteroid Dehydrogenase/ Δ<sup>5</sup>-Δ<sup>4</sup>Isomerase Deficiency

1 Jan 2002

Abstract excerpt

The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4)isomerase (3beta-HSD) isoenzymes are responsible for the oxidation and isomerization of Delta(5)-3beta-hydroxysteroid precursors into Delta(4)-ketosteroids, thus catalyzing an essential step in the formation of all classes of active steroid hormones. The 3beta-HSD gene family should have evolved to facilitate differential patterns of tissue- and...

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Identifiers

PMID: 12428206
DOI: 10.1055/s-2002-35373

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