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Article

Analysis of BCLI, N363S and ER22/23EK Polymorphisms of the Glucocorticoid Receptor Gene in Adrenal Incidentalomas.

PloS one - 1 Jan 2016

Reimondo Giuseppe, Chiodini Iacopo, Puglisi Soraya, Pia Anna, Morelli Valentina, Kastelan Darko, Cannavo Salvatore, Berchialla Paola, Giachino Daniela, Perotti Paola, Cuccurullo Alessandra, Paccotti Piero, Beck-Peccoz Paolo, De Marchi Mario, Terzolo Massimo

Abstract excerpt

CONTEXT: Patients with adrenal incidentalomas (AI) may experience detrimental consequences due to a minimal cortisol excess sustained by adrenal adenoma. SNPs of the glucocorticoid receptor gene (NR3C1) modulate individual sensitivity to glucocorticoids and may interfere with the clinical presentation. OBJECTIVE: To compare the frequency of N363S, ER22/23EK and BclI SNPs in patients with AI with the general...

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PMID: 27649075
DOI: 10.1371/journal.pone.0162437
PMCID: PMC5029814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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