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Article

ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.

International journal of molecular sciences - 7 Mar 2017

MacKenzie Scott M, Freel E Marie, Connell John M, Fraser Robert, Davies Eleanor

Abstract excerpt

The majority of genes contributing to the heritable component of blood pressure remain unidentified, but there is substantial evidence to suggest that common polymorphisms at loci involved in the biosynthesis of the corticosteroids aldosterone and cortisol are important. This view is supported by data from genome-wide association studies that consistently link the CYP17A1 locus to blood pressure. In this review...

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Share to Adrenocorticotropic Hormone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP11B2

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Share to Steroid 11-beta-Hydroxylase

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Source

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Identifiers

PMID: 28272372
DOI: 10.3390/ijms18030579
PMCID: PMC5372595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.PMID 28272372Read ↗

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