Article
Association of the variations in the HSD3β gene with primary aldosteronism.
Journal of hypertension - 1 Jul 2013
Wu Vin-Cent, Wu Cho-Kai, Chang Yi-Cheng, Young Guang-Huar, Chen Shann-Ching, Yang Wei-Shiung, Chen Chien-Yuan, Wang Wei-Jie, Lin Chien-Yu, Lin Yen-Hung, Lin Shuei-Liong, Chueh Shih-Chieh, Wu Kwan-Dun
Abstract excerpt
OBJECTIVE: In mice, a lack of cryptochrome results in up-regulation of aldosterone production due to high expression of the 3β-hydroxysteroid dehydrogenases (HSD3β) gene. The HSD3β pathway might play a pivotal role in aldosterone synthesis. This study aimed to determine the association of HSD3β and HSD3β2 gene variations with primary aldosteronism in a Taiwanese population. METHOD: In this case-control cohort,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.